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Integration of metabolic network and regulatory network models

Metabolic and regulatory systems are highly inter-dependent. Regulatory network components can affect the metabolic components through the expression of proteins that catalyze metabolic reactions. On the other hand, metabolites can activate or repress transcription factor (TF) expressions and thus, influence the regulatory network behavior. However, there had not been too many attempts to integrate these [...]

Gradual Evolution of Robustness

There is a common belief that most biological networks are robust enough to sustain changes in environmental condition (noise) and sudden mutations. However, how the robustness may have evolved through the process of natural selection remains relatively unexplored in the current literature. A recent work by Cilberti et al. attempts to get an insight on this [...]